2. Factor VII deficiency.
Most cases of hemophilia are caused as a result of a Factor VII deficiency. There are a total of 13 clotting factors, or proteins, within the blood; however, these genes can become mutated, and as a result, blood clotting can be affected. A deficiency in Factor VII is the most common cause of hemophilia or hemophilia A.
According to medical researchers, 8 out of 10 people who suffer from this bleeding disorder have hemophilia A. The mutation of Factor VII is inherited or passed on from one family member to another; both males and females can pass it onto their children.
While males who pass on this genetic mutation may experience symptoms of hemophilia themselves, females who pass on this genetic mutation usually don’t exhibit symptoms of the disorder. Additionally, males are more likely to exhibit signs, while it is very rare for females to exhibit symptoms.