4. Fragile Bones
You’ll find that people with Cushing’s disease have fragile bones due to decreased bone density. What many people don’t know is that Cortisol tends to trigger bone mineral reabsorption. During this process, the bones are broken down into minerals such as calcium and released into the bloodstream.
In individuals with Cushing’s disease, this bone reabsorption process is meant to encourage bone growth and strength to take place through gluconeogenesis. This can impair bone formation. Yes, in Cushing’s disease the bone absorption and the formation process doesn’t happen as it should in a healthy body. This leads to a decrease in the absorption of calcium and everyone knows that calcium is imperative for developing strong and healthy bones.
It also decreases bone cell growth. Elevated cortisol levels can directly inhibit bone formation. This is why it’s common for people with Cushing’s disease to also be diagnosed with osteoporosis. Fragile bones will leave one susceptible to fractures which can be very harmful.
In individuals with Cushing’s disease, this bone reabsorption process is meant to encourage bone growth and strength to take place through gluconeogenesis. This can impair bone formation. Yes, in Cushing’s disease the bone absorption and the formation process doesn’t happen as it should in a healthy body.
This leads to a decrease in the absorption of calcium and everyone knows that calcium is imperative for developing strong and healthy bones. It also decreases bone cell growth. Elevated cortisol levels can directly inhibit bone formation. This is why it’s common for people with Cushing’s disease to also be diagnosed with osteoporosis. Fragile bones will leave one susceptible to fractures which can be very harmful.